Structural and mechanistic insights into mechanoactivation of focal adhesion kinase

Focal adhesion kinase (FAK) is a key signaling molecule regulating cell adhesion, migration, and survival. FAK localizes into focal adhesion complexes formed at the cytoplasmic side of cell attachment to the ECM and is activated after force generation via actomyosin fibers attached to this complex....

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bauer, Magnus Sebastian, Baumann, Fabian, Daday, Csaba, Redondo, Pilar, Durner, Ellis, Jobst, Markus Andreas, Milles, Lukas Frederik, Mercadante, Davide, Pippig, Diana Angela, Gaub, Hermann Eduard, Gräter, Frauke, Lietha, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452671/
https://ncbi.nlm.nih.gov/pubmed/30877242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820567116
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