The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination

Hematopoietic stem cell (HSC) homeostasis is controlled by cytokine receptor–mediated Janus kinase 2 (JAK2) signaling. We previously found that JAK2 is promptly ubiquitinated upon cytokine stimulation. Whether a competing JAK2 deubiquitination activity exists is unknown. LNK is an essential adaptor...

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Foilsithe in:Blood
Main Authors: Donaghy, Ryan, Han, Xu, Rozenova, Krasimira, Lv, Kaosheng, Jiang, Qinqin, Doepner, Miriam, Greenberg, Roger A., Tong, Wei
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2019
Ábhair:
Hematopoiesis and Stem Cells
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450430/
https://ncbi.nlm.nih.gov/pubmed/30755420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-10-877563
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