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MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling

Hematopoietic stem cell (HSC) self-renewal and multilineage reconstitution are controlled by positive and negative signaling cues with perturbations leading to disease. Lnk is an essential signaling adaptor protein that dampens signaling by the cytokine thrombopoietin (Tpo) to limit HSC expansion. H...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Rozenova, Krasimira, Jiang, Jing, Donaghy, Ryan, Aressy, Bernadette, Greenberg, Roger A., Tong, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357581/
https://ncbi.nlm.nih.gov/pubmed/25636339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-588145
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