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MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling

Hematopoietic stem cell (HSC) self-renewal and multilineage reconstitution are controlled by positive and negative signaling cues with perturbations leading to disease. Lnk is an essential signaling adaptor protein that dampens signaling by the cytokine thrombopoietin (Tpo) to limit HSC expansion. H...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Rozenova, Krasimira, Jiang, Jing, Donaghy, Ryan, Aressy, Bernadette, Greenberg, Roger A., Tong, Wei
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357581/
https://ncbi.nlm.nih.gov/pubmed/25636339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-588145
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