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Lnk deficiency partially mitigates hematopoietic stem cell aging
Upon aging, the number of hematopoietic stem cells (HSCs) in the bone marrow increases while their repopulation potential declines. Moreover, aged HSCs exhibit lineage bias in reconstitution experiments with an inclination towards myeloid at the expense of lymphoid potential. The adaptor protein Lnk...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3500428/ https://ncbi.nlm.nih.gov/pubmed/22812478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00862.x |
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