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Lnk deficiency partially mitigates hematopoietic stem cell aging

Upon aging, the number of hematopoietic stem cells (HSCs) in the bone marrow increases while their repopulation potential declines. Moreover, aged HSCs exhibit lineage bias in reconstitution experiments with an inclination towards myeloid at the expense of lymphoid potential. The adaptor protein Lnk...

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Bibliografiske detaljer
Main Authors: Bersenev, Alexey, Rozenova, Krasimira, Balcerek, Joanna, Jiang, Jing, Wu, Chao, Tong, Wei
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500428/
https://ncbi.nlm.nih.gov/pubmed/22812478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00862.x
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