Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia

Fanconi anemia (FA) is a bone marrow failure (BMF) syndrome that arises from mutations in a network of FA genes essential for DNA interstrand crosslink (ICL) repair and replication stress tolerance. While allogeneic stem cell transplantation can replace defective HSCs, interventions to mitigate HSC...

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Publicat a:Nat Commun
Autors principals: Balcerek, Joanna, Jiang, Jing, Li, Yang, Jiang, Qinqin, Holdreith, Nicholas, Singh, Brijendra, Chandra, Vemika, Lv, Kaosheng, Ren, Jian-gang, Rozenova, Krasimira, Li, Weihua, Greenberg, Roger A., Tong, Wei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156422/
https://ncbi.nlm.nih.gov/pubmed/30254368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06380-1
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