Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage

Interstrand crosslinks (ICLs) of the DNA helix are a deleterious form of DNA damage. ICLs can be repaired by the Fanconi anemia pathway. At the center of the pathway is the FANCD2/FANCI complex, recruitment of which to DNA is a critical step for repair. After recruitment, monoubiquitination of both...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Lopez-Martinez, David, Kupculak, Marian, Yang, Di, Yoshikawa, Yasunaga, Liang, Chih-Chao, Wu, Ronghu, Gygi, Steven P., Cohn, Martin A.
Format: Artigo
Language:Inglês
Published: Cell Press 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581795/
https://ncbi.nlm.nih.gov/pubmed/31167143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.003
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