Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase

Fanconi anemia (FA) pathway members, FANCD2 and FANCI, contribute to the repair of replication-stalling DNA lesions. FA pathway activation relies on phosphorylation of FANCI by the ataxia telangiectasia and Rad3-related (ATR) kinase, followed by monoubiquitination of FANCD2 and FANCI by the FA core...

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Hlavní autoři: Sareen, Archana, Chaudhury, Indrajit, Adams, Nicole, Sobeck, Alexandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458572/
https://ncbi.nlm.nih.gov/pubmed/22753026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks638
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