LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis

RATIONALE: Human genome wide association studies (GWAS) have revealed novel genetic loci that are associated with coronary heart disease (CHD). One such locus resides in LNK/SH2B3 which in mice is expressed in hematopoietic cells and suppresses thrombopoietin (TPO) signaling via its receptor MPL. Ho...

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Udgivet i:Circ Res
Main Authors: Wang, Wei, Tang, Yang, Wang, Ying, Tascau, Liana, Balcerek, Joanna, Tong, Wei, Levine, Ross L., Welch, Carrie, Tall, Alan R., Wang, Nan
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016083/
https://ncbi.nlm.nih.gov/pubmed/27430239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308955
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