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Specificity of the BRISC Deubiquitinating Enzyme Is Not Due to Selective Binding to Lys(63)-linked Polyubiquitin

BRISC (Brcc36-containing isopeptidase complex) is a four-subunit deubiquitinating (DUB) enzyme that has a catalytic subunit, called Brcc36, that is a member of the JAMM/MPN(+) family of zinc metalloproteases. A notable feature of BRISC is its high specificity for cleaving Lys(63)-linked polyubiquiti...

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Main Authors: Cooper, Eric M., Boeke, Jef D., Cohen, Robert E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856240/
https://ncbi.nlm.nih.gov/pubmed/20032457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059667
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