Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13

UBC13 is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UEV1a or MMS2. Lys-63-linked ubiquitination is crucial for recruitment of DNA repair and damage response molecules to sites of DNA double-strand breaks (DSBs). A deubiquitin...

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Detalhes bibliográficos
Main Authors: Sato, Yusuke, Yamagata, Atsushi, Goto-Ito, Sakurako, Kubota, Keiko, Miyamoto, Rikako, Nakada, Shinichiro, Fukai, Shuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406671/
https://ncbi.nlm.nih.gov/pubmed/22679021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364752
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