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Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13
UBC13 is the only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UEV1a or MMS2. Lys-63-linked ubiquitination is crucial for recruitment of DNA repair and damage response molecules to sites of DNA double-strand breaks (DSBs). A deubiquitin...
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Główni autorzy: | , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
American Society for Biochemistry and Molecular Biology
2012
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406671/ https://ncbi.nlm.nih.gov/pubmed/22679021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364752 |
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