Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3

TAB2 and TAB3 activate the Jun N-terminal kinase and nuclear factor-κB pathways through the specific recognition of Lys 63-linked polyubiquitin chains by its Npl4 zinc-finger (NZF) domain. Here we report crystal structures of the TAB2 and TAB3 NZF domains in complex with Lys 63-linked diubiquitin at...

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Detalhes bibliográficos
Main Authors: Sato, Yusuke, Yoshikawa, Azusa, Yamashita, Masami, Yamagata, Atsushi, Fukai, Shuya
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797061/
https://ncbi.nlm.nih.gov/pubmed/19927120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.345
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