The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys(63) Linkages in Mixed Linkage Ubiquitin Chains

Ubiquitin chain complexity in cells is likely regulated by a diverse set of deubiquitinating enzymes (DUBs) with distinct ubiquitin chain preferences. Here we show that the polyglutamine disease protein, ataxin-3, binds and cleaves ubiquitin chains in a manner suggesting that it functions as a mixed...

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Detalhes bibliográficos
Main Authors: Winborn, Brett J., Travis, Sue M., Todi, Sokol V., Scaglione, K. Matthew, Xu, Ping, Williams, Aislinn J., Cohen, Robert E., Peng, Junmin, Paulson, Henry L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546540/
https://ncbi.nlm.nih.gov/pubmed/18599482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803692200
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