Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117

Deubiquitinating enzymes (DUbs) play important roles in many ubiquitin-dependent pathways, yet how DUbs themselves are regulated is not well understood. Here, we provide insight into the mechanism by which ubiquitination directly enhances the activity of ataxin-3, a DUb implicated in protein quality...

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Bibliografski detalji
Glavni autori: Todi, Sokol V., Scaglione, K. Matthew, Blount, Jessica R., Basrur, Venkatesha, Conlon, Kevin P., Pastore, Annalisa, Elenitoba-Johnson, Kojo, Paulson, Henry L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Enzymology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998082/
https://ncbi.nlm.nih.gov/pubmed/20943656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.181610
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