The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates

Attachment of ubiquitin to substrate is typically thought to occur via formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and a lysine residue in the substrate. In vitro, Ube2w is nonreactive with free lysine yet readily ubiquitinates substrate. Ube2w also contains n...

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Main Authors: Scaglione, Kenneth Matthew, Basrur, Venkatesha, Ashraf, Naila S., Konen, John R., Elenitoba-Johnson, Kojo S. J., Todi, Sokol V., Paulson, Henry L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696654/
https://ncbi.nlm.nih.gov/pubmed/23696636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.477596
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