Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems

UBE2W ubiquitinates N termini of proteins rather than internal lysine residues, showing a preference for substrates with intrinsically disordered N termini. The in vivo functions of this intriguing E2, however, remain unknown. We generated Ube2w germ line KO mice that proved to be susceptible to ear...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Bo, Merillat, Sean A., Vincent, Michael, Huber, Amanda K., Basrur, Venkatesha, Mangelberger, Doris, Zeng, Li, Elenitoba-Johnson, Kojo, Miller, Richard A., Irani, David N., Dlugosz, Andrzej A., Schnell, Santiago, Scaglione, Kenneth Matthew, Paulson, Henry L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742764/
https://ncbi.nlm.nih.gov/pubmed/26601958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676601
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados