Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems

UBE2W ubiquitinates N termini of proteins rather than internal lysine residues, showing a preference for substrates with intrinsically disordered N termini. The in vivo functions of this intriguing E2, however, remain unknown. We generated Ube2w germ line KO mice that proved to be susceptible to ear...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Wang, Bo, Merillat, Sean A., Vincent, Michael, Huber, Amanda K., Basrur, Venkatesha, Mangelberger, Doris, Zeng, Li, Elenitoba-Johnson, Kojo, Miller, Richard A., Irani, David N., Dlugosz, Andrzej A., Schnell, Santiago, Scaglione, Kenneth Matthew, Paulson, Henry L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742764/
https://ncbi.nlm.nih.gov/pubmed/26601958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676601
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