The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington’s Disease protein, huntingtin

Huntington’s Disease (HD) is caused by a CAG repeat expansion that encodes a polyglutamine (polyQ) expansion in the HD disease protein, huntingtin (HTT). PolyQ expansion promotes misfolding and aggregation of mutant HTT (mHTT) within neurons. The cellular pathways, including ubiquitin-dependent proc...

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Foilsithe in:Neurobiol Dis
Main Authors: Wang, Bo, Zeng, Li, Merillat, Sean A, Ochaba, Joseph, Thompson, Leslie M, Barmada, Sami J, Scaglione, Kenneth M, Paulson, Henry L
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973538/
https://ncbi.nlm.nih.gov/pubmed/28986324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.10.002
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