Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP

The mechanisms by which ubiquitin ligases are regulated remain poorly understood. Here we describe a series of molecular events that coordinately regulate CHIP, a neuroprotective E3 implicated in protein quality control. Through their opposing activities, the initiator E2, Ube2w, and the specialized...

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Main Authors: Scaglione, K. Matthew, Zavodszky, Eszter, Todi, Sokol V., Patury, Srikanth, Xu, Ping, Rodríguez-Lebrón, Edgardo, Fischer, Svetlana, Konen, John, Djarmati, Ana, Peng, Junmin, Gestwicki, Jason E., Paulson, Henry L.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166620/
https://ncbi.nlm.nih.gov/pubmed/21855799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.05.036
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