CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of hematopoietic neoplasms. However, molecular mechanisms underlying the regulation of JAK2 have remained elusive. Here we report that the Casitas...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Lv, Kaosheng, Jiang, Jing, Donaghy, Ryan, Riling, Christopher R., Cheng, Ying, Chandra, Vemika, Rozenova, Krasimira, An, Wei, Mohapatra, Bhopal C., Goetz, Benjamin T., Pillai, Vinodh, Han, Xu, Todd, Emily A., Jeschke, Grace R., Langdon, Wallace Y., Kumar, Suresh, Hexner, Elizabeth O., Band, Hamid, Tong, Wei
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495118/
https://ncbi.nlm.nih.gov/pubmed/28611190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.297135.117
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