CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of hematopoietic neoplasms. However, molecular mechanisms underlying the regulation of JAK2 have remained elusive. Here we report that the Casitas...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Lv, Kaosheng, Jiang, Jing, Donaghy, Ryan, Riling, Christopher R., Cheng, Ying, Chandra, Vemika, Rozenova, Krasimira, An, Wei, Mohapatra, Bhopal C., Goetz, Benjamin T., Pillai, Vinodh, Han, Xu, Todd, Emily A., Jeschke, Grace R., Langdon, Wallace Y., Kumar, Suresh, Hexner, Elizabeth O., Band, Hamid, Tong, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495118/
https://ncbi.nlm.nih.gov/pubmed/28611190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.297135.117
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