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K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

An unusual deubiquitinating (DUB) activity exists in HeLa cell extracts that is highly specific for cleaving K63-linked but not K48-linked polyubiquitin chains. The activity is insensitive to both N-ethyl-maleimide and ubiquitin aldehyde, indicating that it lacks an active site cysteine residue, and...

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Detaylı Bibliyografya
Asıl Yazarlar: Cooper, Eric M, Cutcliffe, Colleen, Kristiansen, Troels Z, Pandey, Akhilesh, Pickart, Cecile M, Cohen, Robert E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666030/
https://ncbi.nlm.nih.gov/pubmed/19214193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.27
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