SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy

HIV-1 Tat is a key regulator of viral transcription, however little is known about the mechanisms that control its turnover in T cells. Here we use a novel proteomics technique, called DiffPOP, to identify the molecular target of JIB-04, a small molecule compound that potently and selectively blocks...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Xu, Muyu, Moresco, James J., Chang, Max, Mukim, Amey, Smith, Davey, Diedrich, Jolene K., Yates, John R., Jones, Katherine A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988312/
https://ncbi.nlm.nih.gov/pubmed/29791506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007071
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