Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Thrombosis is a major cause of morbidity and mortality in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), clonal disorders of hematopoiesis characterized by activated JAK-STAT signaling. Neutrophil extracellular trap (NET) formation, a component of innate immunity, has been lin...

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Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Wolach, Ofir, Sellar, Rob S., Martinod, Kimberly, Cherpokova, Deya, McConkey, Marie, Chappell, Ryan J., Silver, Alexander J, Adams, Dylan, Castellano, Cecilia A, Schneider, Rebekka K., Padera, Robert F., DeAngelo, Daniel J., Wadleigh, Martha, Steensma, David P., Galinsky, Ilene, Stone, Richard M., Genovese, Giulio, McCarroll, Steven A., Iliadou, Bozenna, Hultman, Christina, Neuberg, Donna, Mullally, Ann, Wagner, Denisa D., Ebert, Benjamin L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442466/
https://ncbi.nlm.nih.gov/pubmed/29643232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan8292
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