Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Thrombosis is a major cause of morbidity and mortality in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), clonal disorders of hematopoiesis characterized by activated JAK-STAT signaling. Neutrophil extracellular trap (NET) formation, a component of innate immunity, has been lin...

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Publicado no:Sci Transl Med
Main Authors: Wolach, Ofir, Sellar, Rob S., Martinod, Kimberly, Cherpokova, Deya, McConkey, Marie, Chappell, Ryan J., Silver, Alexander J, Adams, Dylan, Castellano, Cecilia A, Schneider, Rebekka K., Padera, Robert F., DeAngelo, Daniel J., Wadleigh, Martha, Steensma, David P., Galinsky, Ilene, Stone, Richard M., Genovese, Giulio, McCarroll, Steven A., Iliadou, Bozenna, Hultman, Christina, Neuberg, Donna, Mullally, Ann, Wagner, Denisa D., Ebert, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442466/
https://ncbi.nlm.nih.gov/pubmed/29643232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan8292
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