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The Molecular Genetics of Myeloproliferative Neoplasms
Activated JAK-STAT signaling is central to the pathogenesis of BCR-ABL-negative myeloproliferative neoplasms (MPNs) and occurs as a result of MPN phenotypic driver mutations in JAK2, CALR, or MPL. The spectrum of concomitant somatic mutations in other genes has now largely been defined in MPNs. With...
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| Pubblicato in: | Cold Spring Harb Perspect Med |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996444/ https://ncbi.nlm.nih.gov/pubmed/31548225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a034876 |
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