Negative Impact of Carbapenem Methylation on the Reactivity of β-Lactams for Cysteine Acylation as Revealed by Quantum Calculations and Kinetic Analyses

The Enterococcus faecium l,d-transpeptidase (Ldt(fm)) mediates resistance to most β-lactam antibiotics in this bacterium by replacing classical peptidoglycan polymerases. The catalytic Cys of Ldt(fm) is rapidly acylated by β-lactams belonging to the carbapenem class but not by penams or cephems. We...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Bhattacharjee, Nicholus, Triboulet, Sébastien, Dubée, Vincent, Fonvielle, Matthieu, Edoo, Zainab, Hugonnet, Jean-Emmanuel, Ethève-Quelquejeu, Mélanie, Simorre, Jean-Pierre, Field, Martin J., Arthur, Michel, Bougault, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437502/
https://ncbi.nlm.nih.gov/pubmed/30718252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02039-18
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