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The structure of Enterococcus Faecium l,d–transpeptidase acylated by ertapenem provides insight into the inactivation mechanism
The maintenance of bacterial cell shape and integrity is largely attributed to peptidoglycan, a biopolymer highly cross-linked through d,d–transpeptidation. Peptidoglycan cross-linking is catalyzed by Penicillin-Binding Proteins (PBPs) that are the essential target of β-lactam antibiotics. PBPs are...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4013547/ https://ncbi.nlm.nih.gov/pubmed/23574509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4001603 |
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