Kinetic Analysis of Enterococcus faecium l,d-Transpeptidase Inactivation by Carbapenems

Bypass of classical penicillin-binding proteins by the l,d-transpeptidase of Enterococcus faecium (Ldt(fm)) leads to high-level ampicillin resistance in E. faecium mutants, whereas carbapenems remain the lone highly active β-lactams. Kinetics of Ldt(fm) inactivation was determined for four commercia...

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Autores principales: Dubée, Vincent, Arthur, Michel, Fief, Hélène, Triboulet, Sébastien, Mainardi, Jean-Luc, Gutmann, Laurent, Sollogoub, Matthieu, Rice, Louis B., Ethève-Quelquejeu, Mélanie, Hugonnet, Jean-Emmanuel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Chemistry; Biosynthesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370759/
https://ncbi.nlm.nih.gov/pubmed/22450984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06398-11
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