In Vitro Cross-Linking of Mycobacterium tuberculosis Peptidoglycan by l,d-Transpeptidases and Inactivation of These Enzymes by Carbapenems

The Mycobacterium tuberculosis peptidoglycan is cross-linked mainly by l,d-transpeptidases (LDTs), which are efficiently inactivated by a single β-lactam class, the carbapenems. Development of carbapenems for tuberculosis treatment has recently raised considerable interest since these drugs, in asso...

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Bibliographische Detailangaben
Hauptverfasser: Cordillot, Mathilde, Dubée, Vincent, Triboulet, Sébastien, Dubost, Lionel, Marie, Arul, Hugonnet, Jean-Emmanuel, Arthur, Michel, Mainardi, Jean-Luc
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837840/
https://ncbi.nlm.nih.gov/pubmed/24041897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01663-13
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