Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase Ldt(Mt1) by Carbapenems and Cephalosporins

The structure of Mycobacterium tuberculosis peptidoglycan is atypical since it contains a majority of 3→3 cross-links synthesized by l,d-transpeptidases that replace 4→3 cross-links formed by the d,d-transpeptidase activity of classical penicillin-binding proteins. Carbapenems inactivate these l,d-t...

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Autores principales: Dubée, Vincent, Triboulet, Sébastien, Mainardi, Jean-Luc, Ethève-Quelquejeu, Mélanie, Gutmann, Laurent, Marie, Arul, Dubost, Lionel, Hugonnet, Jean-Emmanuel, Arthur, Michel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
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Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421625/
https://ncbi.nlm.nih.gov/pubmed/22615283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00665-12
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