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Negative Impact of Carbapenem Methylation on the Reactivity of β-Lactams for Cysteine Acylation as Revealed by Quantum Calculations and Kinetic Analyses
The Enterococcus faecium l,d-transpeptidase (Ldt(fm)) mediates resistance to most β-lactam antibiotics in this bacterium by replacing classical peptidoglycan polymerases. The catalytic Cys of Ldt(fm) is rapidly acylated by β-lactams belonging to the carbapenem class but not by penams or cephems. We...
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| Gepubliceerd in: | Antimicrob Agents Chemother |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Microbiology
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6437502/ https://ncbi.nlm.nih.gov/pubmed/30718252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02039-18 |
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