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Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators
Allosteric ligands bind to receptors at sites that are distinct from those endogenous agonists and orthosteric pharmacological agents interact with. Both an allosteric and orthosteric ligand bind simultaneously to the receptor to form a ternary complex, where each ligand influences binding affinity...
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| I publikationen: | PLoS One |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6436737/ https://ncbi.nlm.nih.gov/pubmed/30917186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0214255 |
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