Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors

Interaction of orthosteric ligands with extracellular domain was described at several aminergic G protein-coupled receptors, including muscarinic acetylcholine receptors. The orthosteric antagonists quinuclidinyl benzilate (QNB) and N-methylscopolamine (NMS) bind to the binding pocket of the muscari...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Jakubík, Jan, Randáková, Alena, Zimčík, Pavel, El-Fakahany, Esam E., Doležal, Vladimír
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238504/
https://ncbi.nlm.nih.gov/pubmed/28091608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40381
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