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Structure-Guided Modification of Heterocyclic Antagonists of the P2Y(14) Receptor
The P2Y(14) receptor (P2Y(14)R) mediates inflammatory activity by activating neutrophil motility, but few classes of antagonists are known. We have explored the structure activity relationship of a 3-(4-phenyl- 1H-1,2,3-triazol-1-yl)-5-(aryl)benzoic acid antagonist scaffold, assisted by docking and...
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| Veröffentlicht in: | J Med Chem |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6428052/ https://ncbi.nlm.nih.gov/pubmed/29767967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00168 |
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