Targeting Processive Transcription Elongation Via SEC Disruption for Myc Induced Cancer Therapy

The Super Elongation Complex (SEC) is required for robust and productive transcription through release of RNA Polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC contributes to multiple human diseases including cancer. He...

Full description

Saved in:
Bibliographic Details
Published in:Cell
Main Authors: Liang, Kaiwei, Smith, Edwin R., Aoi, Yuki, Stoltz, Kristen L., Katagi, Hiroaki, Woodfin, Ashley R., Rendleman, Emily J., Marshall, Stacy A., Murray, David C., Wang, Lu, Ozark, Patrick A., Mishra, Rama K., Hashizume, Rintaro, Schiltz, Gary E., Shilatifard, Ali
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422358/
https://ncbi.nlm.nih.gov/pubmed/30340042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.09.027
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items