NELF regulates a promoter-proximal step distinct from RNA Pol II pause-release

RNA polymerase II (RNA Pol II) is generally paused at promoter-proximal regions in most metazoans, and based on in vitro studies, this function has been attributed to the negative elongation factor (NELF). Here, we show that upon rapid depletion of NELF, RNA Pol II fails to be released into gene bod...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Aoi, Yuki, Smith, Edwin R., Shah, Avani P., Rendleman, Emily J., Marshall, Stacy A., Woodfin, Ashley R., Chen, Fei X., Shiekhattar, Ramin, Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402197/
https://ncbi.nlm.nih.gov/pubmed/32155413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.02.014
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