NELF regulates a promoter-proximal step distinct from RNA Pol II pause-release

RNA polymerase II (RNA Pol II) is generally paused at promoter-proximal regions in most metazoans, and based on in vitro studies, this function has been attributed to the negative elongation factor (NELF). Here, we show that upon rapid depletion of NELF, RNA Pol II fails to be released into gene bod...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Aoi, Yuki, Smith, Edwin R., Shah, Avani P., Rendleman, Emily J., Marshall, Stacy A., Woodfin, Ashley R., Chen, Fei X., Shiekhattar, Ramin, Shilatifard, Ali
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402197/
https://ncbi.nlm.nih.gov/pubmed/32155413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.02.014
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