NELF regulates a promoter-proximal step distinct from RNA Pol II pause-release

RNA polymerase II (RNA Pol II) is generally paused at promoter-proximal regions in most metazoans, and based on in vitro studies, this function has been attributed to the negative elongation factor (NELF). Here, we show that upon rapid depletion of NELF, RNA Pol II fails to be released into gene bod...

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Publicado en:Mol Cell
Autores principales: Aoi, Yuki, Smith, Edwin R., Shah, Avani P., Rendleman, Emily J., Marshall, Stacy A., Woodfin, Ashley R., Chen, Fei X., Shiekhattar, Ramin, Shilatifard, Ali
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402197/
https://ncbi.nlm.nih.gov/pubmed/32155413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.02.014
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