Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is associated with transcriptional dysregulation driven by H3K27 mutation. The super elongation complex (SEC) is required for transcriptional elongation through release of RNA polymerase II (Pol II). Inhibition of transcription elongation by SEC di...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Katagi, Hiroaki, Takata, Nozomu, Aoi, Yuki, Zhang, Yongzhan, Rendleman, Emily J, Blyth, Gavin T, Eckerdt, Frank D, Tomita, Yusuke, Sasaki, Takahiro, Saratsis, Amanda M, Kondo, Akihide, Goldman, Stewart, Becher, Oren J, Smith, Edwin, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Pediatric Neuro-Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328031/
https://ncbi.nlm.nih.gov/pubmed/33471107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab009
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