DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma (DIPG) is highly aggressive brain stem tumor and needed to develop novel therapeutic agents for the treatment. The super elongation complex (SEC) is essential for transcription elongation through release of RNA polymerase II (Pol II). We found that AFF4, a scaffold p...

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Foilsithe in:Neuro Oncol
Main Authors: Katagi, Hiroaki, Takata, Nozomu, Aoi, Yuki, Zhang, Yongzhan, Rendleman, Emily J, Blyth, Gavin T, Eckerdt, Frank D, Tomita, Yusuke, Sasaki, Takahiro, Saratsis, Amanda M, Kondo, Akihide, Goldman, Stewart, Becher, Oren J, Smith, Edwin, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Diffuse Midline Glioma/DIPG
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715649/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.055
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