DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma (DIPG) is highly aggressive brain stem tumor and needed to develop novel therapeutic agents for the treatment. The super elongation complex (SEC) is essential for transcription elongation through release of RNA polymerase II (Pol II). We found that AFF4, a scaffold p...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Katagi, Hiroaki, Takata, Nozomu, Aoi, Yuki, Zhang, Yongzhan, Rendleman, Emily J, Blyth, Gavin T, Eckerdt, Frank D, Tomita, Yusuke, Sasaki, Takahiro, Saratsis, Amanda M, Kondo, Akihide, Goldman, Stewart, Becher, Oren J, Smith, Edwin, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Diffuse Midline Glioma/DIPG
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715649/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.055
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