DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma (DIPG) is highly aggressive brain stem tumor and needed to develop novel therapeutic agents for the treatment. The super elongation complex (SEC) is essential for transcription elongation through release of RNA polymerase II (Pol II). We found that AFF4, a scaffold p...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Katagi, Hiroaki, Takata, Nozomu, Aoi, Yuki, Zhang, Yongzhan, Rendleman, Emily J, Blyth, Gavin T, Eckerdt, Frank D, Tomita, Yusuke, Sasaki, Takahiro, Saratsis, Amanda M, Kondo, Akihide, Goldman, Stewart, Becher, Oren J, Smith, Edwin, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Diffuse Midline Glioma/DIPG
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715649/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.055
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