PDTM-42. TARGETED INHIBITION OF BET BROMODOMAIN AND JMJD3 PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA

Recent discovery of somatic histone gene mutations, resulting in replacement of lysine 27 by methionine (K27M) in the encoded histone H3.3 proteins, in diffuse intrinsic pontine glioma (DIPG) has dramatically improved our understanding of disease pathogenesis, and stimulated the development of novel...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Katagi, Hiroaki, Zhang, Ali, T. Blyth, Gavin, D. Eckerdt, Frank, A. Ozark, Patrick, Zou, Lihua, He, Xingyao, E. Loughlin, Kathryn, Sasaki, Takahiro, Horbinski, Craig, R. Lulla, Rishi, M. Saratsis, Amanda, Goldman, Stewart, David James, C, Shilatifard, Ali, Hashizume, Rintaro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Abstracts
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217467/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.881
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