PDTM-42. TARGETED INHIBITION OF BET BROMODOMAIN AND JMJD3 PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA

Recent discovery of somatic histone gene mutations, resulting in replacement of lysine 27 by methionine (K27M) in the encoded histone H3.3 proteins, in diffuse intrinsic pontine glioma (DIPG) has dramatically improved our understanding of disease pathogenesis, and stimulated the development of novel...

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Publicado no:Neuro Oncol
Main Authors: Katagi, Hiroaki, Zhang, Ali, T. Blyth, Gavin, D. Eckerdt, Frank, A. Ozark, Patrick, Zou, Lihua, He, Xingyao, E. Loughlin, Kathryn, Sasaki, Takahiro, Horbinski, Craig, R. Lulla, Rishi, M. Saratsis, Amanda, Goldman, Stewart, David James, C, Shilatifard, Ali, Hashizume, Rintaro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217467/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.881
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