DIPG-14. INTEGRATED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) NEXT-GENERATION SEQUENCING REVEALS EPIGENETIC DYSREGULATION OF GENE EXPRESSION AND BROMODOMAIN INHIBITION AS A NOVEL THERAPEUTIC TARGET

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) has the highest mortality of all pediatric solid tumors. Histone H3 mutation (H3K27M) occurs in 80%, altering chromatin structure and function. To characterize the effects of H3K27M as an oncogenic driver, we analyzed the transcriptome and epigen...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Saratsis, Amanda, Piunti, Andrea, Huang, Tina, Bartom, Elizaeth, Ozark, Patrick, Marshall, Stacy, Qi, Jin, Hashizume, Rintaro, Lulla, Rishi, David James, C, Shilatifard, Ali
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012226/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.107
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