PDTM-02. NEXT-GENERATION SEQUENCING OF DIFFUSE INTRINSIC PONTINE GLIOMA CELLS REVEALS ALTERED EPIGENETIC REGULATION AND DISTINCT TUMOR SUBGROUPS

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is an infiltrative neoplasm with the highest mortality rate of all pediatric solid tumors. Recurrent somatic mutations of histone H3 isoforms result in methionine for lysine substitution (H3K27M) in 80% of DIPGs, thought to contribute to tumorige...

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Publicado no:Neuro Oncol
Main Authors: Saratsis, Amanda, Huang, Tina, Bartom, Elizabeth, Marshall, Stacy, Qi, Jin, Hashizume, Rintaro, James, C David, Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692806/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.767
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