PDTM-02. NEXT-GENERATION SEQUENCING OF DIFFUSE INTRINSIC PONTINE GLIOMA CELLS REVEALS ALTERED EPIGENETIC REGULATION AND DISTINCT TUMOR SUBGROUPS

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is an infiltrative neoplasm with the highest mortality rate of all pediatric solid tumors. Recurrent somatic mutations of histone H3 isoforms result in methionine for lysine substitution (H3K27M) in 80% of DIPGs, thought to contribute to tumorige...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Saratsis, Amanda, Huang, Tina, Bartom, Elizabeth, Marshall, Stacy, Qi, Jin, Hashizume, Rintaro, James, C David, Shilatifard, Ali
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Abstracts
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692806/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.767
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