DIPG-24. EPIGENETIC ANALYSIS OF FORMALIN-FIXED PARAFFIN-EMBEDDED PEDIATRIC GLIOMA TISSUE

BACKGROUND: Diffuse midline gliomas are uniquely characterized by missense mutations in Histone H3 isoforms H3.3 and H3.1, associated with distinct gene, protein and methylation profiles and poorer clinical outcomes. As a result, mutant H3 protein is of great interest as a potential driver of pediat...

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Publicado en:Neuro Oncol
Main Authors: Huang, Tina, Piunti, Andrea, Hashizume, Rintaro, Bartom, Elizabeth, Qi, Jin, Tomita, Tadanori, James, C. David, Shilatifard, Ali, Saratsis, Amanda
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474999/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.039
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