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HGG-10. HISTONE H3G34V MUTATION IS SUFFICIENT TO DRIVE DISTINCT GENOMIC H3K36 METHYLATION PATTERNS IN PEDIATRIC GLIOMA
BACKGROUND: Mutations in genes encoding Histone protein isoforms H3.3 (H3F3A and H3F3A) and H3.1 (HIST1H3B) are detected at high frequency in pediatric high-grade glioma (pHGG). Up to 50% of cortical pHGGs bear a point mutation in H3F3A, resulting in replacement of glycine 34 with arginine or valine...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477320/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.104 |
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