Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells

Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), impairing SETD2 activity (H3K36-specific trimethyltransferase). Consequently, reduced H3K36me3 is observed on H3.3G34V nucleosomes relative to wil...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Huang, Tina Yi-Ting, Piunti, Andrea, Qi, Jin, Morgan, Marc, Bartom, Elizabeth, Shilatifard, Ali, Saratsis, Amanda M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722426/
https://ncbi.nlm.nih.gov/pubmed/33287886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01092-4
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