The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. The median survival of this group of patients after diagnosis is ∼1 yr. Here we show that the levels of H3...

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Bibliografiske detaljer
Main Authors: Chan, Kui-Ming, Fang, Dong, Gan, Haiyun, Hashizume, Rintaro, Yu, Chuanhe, Schroeder, Mark, Gupta, Nalin, Mueller, Sabine, James, C. David, Jenkins, Robert, Sarkaria, Jann, Zhang, Zhiguo
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2013
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656328/
https://ncbi.nlm.nih.gov/pubmed/23603901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.217778.113
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