GENE-10. H3K27ME3-MEDIATED SILENCING TUMOR SUPPRESSORS SUPPORTS THE PROLIFERATION OF PEDIATRIC BRAIN TUMOR CELLS HARBORING THE H3.3K27M MUTATION

Recent genetic studies have shown that the lysine 27 to methionine of histone H3.3 (H3.3K27M) mutant proteins expressed in over 75% of diffuse intrinsic pontine glioma (DIPG) cases inhibit H3K27 methyltransferase PRC2, resulting in a global loss of tri-methylation of H3K27 (H3K27me3). In addition, H...

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Publicado no:Neuro Oncol
Main Authors: Fang, Dong, Gan, Haiyun, Cheng, Liang, Lee, Jeong-Heon, Zhou, Hui, Sarkaria, Jann, Daniels, David, Zhang, Zhiguo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475045/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.081
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