GENE-10. H3K27ME3-MEDIATED SILENCING TUMOR SUPPRESSORS SUPPORTS THE PROLIFERATION OF PEDIATRIC BRAIN TUMOR CELLS HARBORING THE H3.3K27M MUTATION

Recent genetic studies have shown that the lysine 27 to methionine of histone H3.3 (H3.3K27M) mutant proteins expressed in over 75% of diffuse intrinsic pontine glioma (DIPG) cases inhibit H3K27 methyltransferase PRC2, resulting in a global loss of tri-methylation of H3K27 (H3K27me3). In addition, H...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Fang, Dong, Gan, Haiyun, Cheng, Liang, Lee, Jeong-Heon, Zhou, Hui, Sarkaria, Jann, Daniels, David, Zhang, Zhiguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Abstracts
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475045/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.081
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky