Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is associated with transcriptional dysregulation driven by H3K27 mutation. The super elongation complex (SEC) is required for transcriptional elongation through release of RNA polymerase II (Pol II). Inhibition of transcription elongation by SEC di...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Katagi, Hiroaki, Takata, Nozomu, Aoi, Yuki, Zhang, Yongzhan, Rendleman, Emily J, Blyth, Gavin T, Eckerdt, Frank D, Tomita, Yusuke, Sasaki, Takahiro, Saratsis, Amanda M, Kondo, Akihide, Goldman, Stewart, Becher, Oren J, Smith, Edwin, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Pediatric Neuro-Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328031/
https://ncbi.nlm.nih.gov/pubmed/33471107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab009
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